nkhani

Pakalipano, kujambula kwa magnetic resonance (MRI) kukukula kuchokera ku zojambula zachikhalidwe ndi zojambula zogwira ntchito kupita ku zojambula za maselo. Multi-nuclear MR Itha kupeza zambiri za metabolite m'thupi la munthu, ndikusunga kusintha kwa malo, kuwongolera kuzindikirika kwa machitidwe a thupi ndi ma pathological, ndipo pakali pano ndiukadaulo wokhawo womwe ungathe kusanthula kuchuluka kwa ma cell amphamvu amunthu mu vivo.

Ndikukula kwa Multi-core MR Research, ili ndi chiyembekezo chogwiritsa ntchito pakuwunika koyambirira ndikuzindikira zotupa, matenda amtima, matenda a neurodegenerative, endocrine system, kugaya chakudya ndi matenda am'mapapo, ndikuwunika mwachangu njira yamankhwala. Pulatifomu yaposachedwa ya Philips yaposachedwa kwambiri yazachipatala ithandiza kulingalira komanso madotolo azachipatala kuchita kafukufuku wotsogola. Dr. Sun Peng ndi Dr. Wang Jiazheng ochokera ku Philips Clinical and Technical Support Department anapereka chidziwitso chatsatanetsatane cha chitukuko cha multi-NMR ndi malangizo ofufuza a Philips 'multi-core MR Platform.

Magnetic resonance yapambana Mphotho ya Nobel kasanu m'mbiri yake, m'magawo onse afizikiki, chemistry, biology, ndi zamankhwala, ndipo yachita bwino kwambiri pa mfundo zoyambira zafiziki, kapangidwe ka maselo achilengedwe, kusinthika kwa ma macromolecular structure, komanso kulingalira kwachipatala. Pakati pawo, kujambula kwa maginito kwakhala imodzi mwamakina ofunikira kwambiri azachipatala, omwe amagwiritsidwa ntchito pozindikira matenda osiyanasiyana m'malo osiyanasiyana a thupi la munthu. Ndi kuwongolera kosalekeza kwa zosowa zachipatala, kufunikira kwakukulu kozindikira msanga komanso kuunika kofulumira kumalimbikitsa chitukuko cha kujambula kwa maginito kuchokera kumalingaliro achikhalidwe (T1w, T2w, PDw, etc.), kujambula kogwira ntchito (DWI, PWI, etc.) mpaka kujambula kwa mamolekyulu (1H MRS Ndi multi-core MRS/MRI).

Kumbuyo kovutirapo kwa 1H yochokera ku MR Technology, mawonekedwe ophatikizika, ndi kuponderezana kwamadzi / mafuta kumachepetsa malo ake ngati ukadaulo woyerekeza ma molekyulu. Mamolekyu owerengeka okha (choline, creatine, NAA, etc.) amatha kudziwika, ndipo n'zovuta kupeza njira zamagetsi zamagetsi. Kutengera mitundu yosiyanasiyana ya ma nuclides (23Na, 31P, 13C, 129Xe, 17O, 7Li, 19F, 3H, 2H), nyukiliya yambiri MR Itha kupeza zambiri zama metabolite m'thupi la munthu, ndikusintha kwakukulu komanso kutsimikizika kwakukulu, ndipo pakali pano ndiyo yokhayo yosasokoneza, yosasunthika, yosasunthika ya isolitestope; (shuga, ma amino acid, mafuta zidulo - zopanda poizoni) pakuwunika kochulukira kwa kagayidwe kazinthu zama cell amunthu.

Ndi kupambana kosalekeza kwa maginito a hardware system, njira yotsatizana mofulumira (Multi-Band, Spiral) ndi ma acceleration algorithm (compressed sensing, deep study), multi-core MR Imaging / spectroscopy imakhwima pang'onopang'ono: (1) ikuyembekezeka kukhala chida chofunikira kwambiri cha biology ya biology, biochemistry ndi kafukufuku wa kagayidwe ka anthu; (2) Pamene akuyenda kuchokera ku kafukufuku wa sayansi kupita ku zochitika zachipatala (mayesero angapo a zachipatala opangidwa ndi ma multi-core MR Akupita patsogolo, FIG. 1), ali ndi chiyembekezo chochuluka pakuwunika koyambirira ndi matenda a khansa, mtima, matenda a neurodegenerative, kugaya ndi kupuma, komanso kuwunika kofulumira kwachangu.

Chifukwa cha zovuta zakuthupi komanso zovuta zaukadaulo za MR Field, Multi-core MR Yakhala gawo lapadera lofufuzira la mabungwe angapo apamwamba ofufuza zaukadaulo. Ngakhale kuti multicore MR Yapita patsogolo kwambiri patatha zaka zambiri zachitukuko, padakalibe chidziwitso chokwanira chachipatala kuti apititse patsogolo ntchitoyi kuti athandize odwala.

Kutengera luso lopitilira muyeso la MR, Philips pomaliza adathyola nkhokwe yachitukuko cha Multi-core MR Ndipo adatulutsa nsanja yatsopano yofufuza zachipatala yomwe ili ndi ma nuclides ambiri pamakampani. Pulatifomu ndiye njira yokhayo padziko lonse lapansi yolandila satifiketi ya EU Safety Conformity Certification (CE) ndi US Food and Drug Administration (FDA), yomwe imathandizira njira yothetsera vuto la MR yamitundu yambiri: Ma coil ovomerezedwa ndi FDA, kuphimba kwathunthu, ndikumanganso koyenera kwa siteshoni. Ogwiritsa ntchito safunika kukhala ndi akatswiri a sayansi ya resonance, akatswiri opanga ma code ndi opanga ma RF gradient, omwe ndi osavuta kuposa 1H spectroscopy/imaging. Kwezani kutsitsa kwamitengo yambiri yogwiritsira ntchito MR, kusintha kwaulere pakati pa kafukufuku wasayansi ndi njira zamankhwala, kuchira kwachangu kwambiri, kuti MR wamagulu angapo alowedi kuchipatala.

Multi-core MR tsopano ndi gawo lofunikira la "14th Five-year Equipment Industry Development Plan", ndipo ndiukadaulo wofunikira kwambiri pakulingalira zachipatala kuti zithe chizolowezicho ndikuphatikiza ndi biomedicine yodula kwambiri. Gulu la asayansi a Philips China, motsogozedwa ndi kuwongolera kafukufuku wamakasitomala ndi luso lazopangapanga, lidachita kafukufuku mwatsatanetsatane pa Multi-core MR. Dr. Sun Peng, Dr. Wang Jiazheng et al. poyamba anapereka lingaliro la MR-nucleomics mu NMR mu Biomedicine (pamwamba Journal of the First Region of Spectroscopy of Chinese Academy of Sciences), yomwe ingagwiritse ntchito MR Kutengera ma nuclides osiyanasiyana kuti ayang'ane ntchito zosiyanasiyana za maselo ndi njira za pathological. Chifukwa chake, kuweruza kwathunthu ndikuwunika matenda ndi chithandizo zitha kupangidwa [1]. Lingaliro la MR Multinucleomics lidzakhala tsogolo la MR Development. Pepala ili ndilo ndondomeko yoyamba yowunikira ma multi-core MR Padziko lonse lapansi, yomwe ikukhudzana ndi maziko a chiphunzitso cha MR yambiri, kafukufuku wachipatala, kusintha kwachipatala, chitukuko cha hardware, kupita patsogolo kwa algorithm, machitidwe a uinjiniya ndi zina (Chithunzi 2). Panthawi imodzimodziyo, gulu la asayansi linagwirizana ndi Pulofesa Song Bin wa ku West China Hospital kuti amalize nkhani yoyamba yowunikira za kusintha kwachipatala kwa Multi-core MR ku China, yomwe inasindikizidwa mu magazini ya Insights into Imaging [2]. Kusindikizidwa kwa zolemba zingapo za multicore MR Kuwonetsa kuti Philips amabweretsadi malire a zithunzithunzi zamitundu yambiri ku China, kwa makasitomala aku China, komanso kwa odwala aku China. Mogwirizana ndi mfundo yaikulu ya "ku China, ku China", Philips adzagwiritsa ntchito ma multi-core MR Kulimbikitsa chitukuko cha maginito a China ndikuthandizira chifukwa cha China chathanzi.

Multi-nuclear MRI ndi teknoloji yomwe ikubwera. Ndi chitukuko cha MR Software ndi hardware, MRI ya nyukiliya yambiri yakhala ikugwiritsidwa ntchito pa kafukufuku woyambirira komanso wachipatala womasulira machitidwe a anthu. Ubwino wake wapadera ndikuti umatha kuwonetsa zochitika zenizeni zenizeni za metabolic m'njira zosiyanasiyana zamatenda, motero zimapereka mwayi wozindikira matenda msanga, kuwunika momwe angagwiritsire ntchito bwino, kupanga chisankho chamankhwala ndikukula kwa mankhwala. Zingathandizenso kufufuza njira zatsopano za pathogenesis.

Pofuna kulimbikitsa chitukuko chowonjezereka cha ntchitoyi, kutenga nawo mbali mwakhama kwa akatswiri azachipatala kumafunika. Kukula kwamapulatifomu ambiri ndikofunikira, kuphatikiza kupanga machitidwe oyambira, kuyimitsidwa kwaukadaulo, kuchulukira ndi kukhazikika kwazotsatira, kufufuzidwa kwa zofufuza zatsopano, kuphatikiza zidziwitso zingapo za metabolic, ndi zina zambiri, kuphatikiza pakupanga mayeso omwe akuyembekezeka kukhala ambiri, kuti apititse patsogolo kusintha kwachipatala kwaukadaulo waukadaulo wa multicore MR. Timakhulupirira kwambiri kuti MR wamagulu ambiri Adzapereka gawo lalikulu kwa akatswiri ojambula ndi akatswiri azachipatala kuti achite kafukufuku wachipatala, ndipo zotsatira zake zidzapindulitsa odwala padziko lonse lapansi.