nkhani

Interferon ndi chizindikiro chomwe chimatulutsidwa ndi kachilomboka m'mimba mwa mbadwa za thupi kuti ayambitse chitetezo cha mthupi, ndipo ndi mzere wodzitetezera ku kachilomboka.Ma interferon a Type I (monga alpha ndi beta) akhala akuphunziridwa kwa zaka zambiri ngati mankhwala oletsa mavairasi.Komabe, zolandilira zamtundu wa I interferon zimawonetsedwa m'matenda ambiri, kotero kuwongolera kwamtundu wa interferon ndikosavuta kupangitsa kuti chitetezo cha mthupi chiwonjezeke, zomwe zimapangitsa kuti pakhale zovuta zingapo.Kusiyana kwake ndikuti ma receptor amtundu wa III interferon (λ) amangowonetsedwa mu minofu ya epithelial ndi ma cell ena achitetezo, monga mapapu, kupuma, matumbo, ndi chiwindi, komwe buku la coronavirus limachita, kotero interferon λ imakhala ndi zotsatirapo zochepa.PEG-λ imasinthidwa ndi polyethylene glycol pamaziko a interferon yachilengedwe λ, ndipo nthawi yake yoyenda m'magazi ndi yayitali kwambiri kuposa ya interferon yachilengedwe.Kafukufuku wambiri wasonyeza kuti PEG-λ imakhala ndi antivayirasi yotakata

Kumayambiriro kwa Epulo 2020, asayansi ochokera ku National Cancer Institute (NCI) ku United States, King's College London ku United Kingdom ndi mabungwe ena ofufuza adasindikiza ndemanga mu J Exp Med yolimbikitsa maphunziro azachipatala pogwiritsa ntchito interferon λ pochiza Covid-19.Raymond T. Chung, mkulu wa Hepatobiliary Center pa Massachusetts General Hospital ku United States, adalengezanso mu Meyi kuti mayeso azachipatala omwe akhazikitsidwa ndi ofufuza adzachitidwa kuti awone kuthandizira kwa PEG-λ motsutsana ndi Covid-19.

Mayesero awiri azachipatala a gawo 2 awonetsa kuti PEG-λ imatha kuchepetsa kwambiri kuchuluka kwa ma virus mwa odwala omwe ali ndi COVID-19 [5,6].Pa february 9, 2023, New England Journal of Medicine (NEJM) idasindikiza zotsatira za gawo lachitatu la kuyesa kwa pulatifomu yotchedwa TOGETHER, motsogozedwa ndi akatswiri aku Brazil ndi Canada, omwe adawunikiranso chithandizo cha PEG-λ pa odwala a COVID-19. [7].

Odwala akunja omwe ali ndi zizindikiro za Covid-19 komanso owonetsa mkati mwa masiku 7 chiyambireni chizindikirocho adalandira PEG-λ (jekeseni imodzi ya subcutaneous, 180 μg) kapena placebo (jekeseni imodzi kapena yapakamwa).Chotsatira chachikulu chinali kugonekedwa m'chipatala (kapena kutumizidwa kuchipatala chapamwamba) kapena kupita ku dipatimenti yadzidzidzi ku Covid-19 mkati mwa masiku 28 atachitika mwachisawawa (kuyang'ana> maola 6).

Coronavirus yatsopano yakhala ikusintha kuyambira kufalikira.Chifukwa chake, ndikofunikira kwambiri kuwona ngati PEG-λ ili ndi zotsatira zochiritsira pamitundu yosiyanasiyana ya coronavirus.Gululo lidasanthula magulu ang'onoang'ono amitundu yosiyanasiyana ya kachilomboka yomwe idapatsira odwala mu mayesowa, kuphatikiza Omicron, Delta, Alpha, ndi Gamma.Zotsatira zinawonetsa kuti PEG-λ inali yothandiza kwa odwala onse omwe ali ndi mitundu iyi, komanso yothandiza kwambiri kwa odwala omwe ali ndi Omicron.

Pankhani ya kuchuluka kwa ma virus, PEG-λ inali ndi chithandizo chofunikira kwambiri kwa odwala omwe ali ndi kuchuluka kwa ma virus, pomwe palibe chithandizo chofunikira kwambiri chomwe chidawonedwa mwa odwala omwe ali ndi ma virus ochepa.Kuchita bwino kumeneku ndi pafupifupi kofanana ndi Pfizer's Paxlovid (Nematovir/Ritonavir).

Dziwani kuti Paxlovid amaperekedwa pakamwa ndi mapiritsi 3 kawiri pa tsiku kwa masiku asanu.PEG-λ, kumbali ina, imangofunika jekeseni imodzi yokhayokha kuti ikwaniritse mphamvu yofanana ndi Paxlovid, kotero imakhala yogwirizana bwino.Kuphatikiza pakutsata, PEG-λ ilinso ndi maubwino ena kuposa Paxlovid.Kafukufuku wasonyeza kuti Paxlovid ndiyosavuta kuyambitsa kuyanjana kwamankhwala komanso kukhudza kagayidwe kazinthu zina.Anthu omwe ali ndi vuto lalikulu la Covid-19, monga odwala okalamba komanso odwala omwe ali ndi matenda osatha, amakonda kumwa mankhwala kwanthawi yayitali, chifukwa chake chiopsezo cha Paxlovid m'magulu awa ndichokwera kwambiri kuposa PEG-λ.

Kuphatikiza apo, Paxlovid ndi inhibitor yomwe imayang'ana ma virus protease.Ngati tizilombo protease mutates, mankhwala angakhale osathandiza.PEG-λ imathandizira kuthetsa ma virus poyambitsa chitetezo cha mthupi, ndipo sichimalimbana ndi ma virus aliwonse.Chifukwa chake, ngakhale kachilomboka kakusintha mtsogolo, PEG-λ ikuyembekezeka kukhalabe yothandiza.

Komabe, FDA idati sichingalole kugwiritsa ntchito PEG-λ mwadzidzidzi, zomwe zidakhumudwitsa asayansi omwe adachita nawo kafukufukuyu.Eiger akunena kuti izi zikhoza kukhala chifukwa chakuti kafukufukuyu sanaphatikizepo malo oyesera zachipatala ku US, komanso chifukwa mayeserowa adayambitsidwa ndi ochita kafukufuku, osati makampani opanga mankhwala.Zotsatira zake, PEG-λ idzafunika kuyika ndalama zambiri komanso nthawi yochulukirapo isanayambike ku United States.

Monga mankhwala oletsa ma virus ambiri, PEG-λ sikuti amangolimbana ndi coronavirus yatsopano, imathanso kupangitsa kuti thupi lizichotsa matenda ena a virus.PEG-λ imakhala ndi zotsatirapo pa virus ya chimfine, kupuma kwa syncytial virus ndi ma coronaviruses ena.Kafukufuku wina wasonyezanso kuti λ interferon mankhwala, ngati atagwiritsidwa ntchito mofulumira, amatha kuletsa kachilomboka kuti zisalowe m'thupi.Eleanor Fish, katswiri wa chitetezo cha m’thupi pa yunivesite ya Toronto ku Canada amene sanachite nawo kafukufuku wa TOGETHER, anati: “Kugwiritsira ntchito kwambiri kwa interferon kwa mtundu umenewu kungakhale njira yodzitetezera, makamaka kuteteza anthu amene ali pangozi yaikulu ku matenda akamabuka.”